Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome

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• 作者：Ronald G. Garcia ; Maritza Perez ; Renke Maas ; Edzard Schwedhelm ; Rainer H. B&#xf6 ; ger ; Patricio L&#xf3 ; pez-Jaramillo
• 关键词：Metabolic syndrome ; Risk factors ; ADMA ; Endothelium ; Inflammation
• 刊名：International Journal of Cardiology
• 出版年：2007
• 期刊代码：128_01675273
• 类别：med
• 出版时间：15 November 2007
• 卷：122
• 期：2
• 页码：176-178
• 文件大小：184 K

摘要

Elevated circulating ADMA levels have been proposed as the pivotal link between insulin resistance, cardiovascular disease, and endothelial dysfunction in Caucasian population. To evaluate whether there is an association between plasma ADMA concentrations and insulin resistance in Hispanic population, we identified metabolic syndrome NCEP-ATP III criteria and measured ADMA and l-arginine plasma concentrations in 147 Colombian young males consecutively included in a cross-sectional study. In contrast to inflammatory markers, ADMA was not found to be elevated in subjects with metabolic syndrome, furthermore, no significant association between ADMA concentrations and insulin resistance degree was found. In conclusion, our results suggest that at least in our population, ADMA does not seem to be implicated in the pathophysiology of metabolic syndrome. Ethnic-specific or environmental differences in the etiologic mechanisms of metabolic syndrome need to be elucidated in further studies.