Interferon gamma and interferon gamma inducible protein-10 in detecting tuberculosis infection

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• 作者：Basirudeen Syed Ahamed Kabeer^a ; Paulkumaran Paramasivam^b ; Alamelu Raja^a ; ^{alameluraja@gmail.com}
• 关键词：Tuberculosis ; Diagnosis ; QuantiFERON-TB Gold ; Interferon gamma inducible protein-10
• 刊名：Journal of Infection
• 出版年：2012
• 期刊代码：6_01634453
• 类别：imm
• 出版时间：June, 2012
• 卷：64
• 期：6
• 页码：573-579
• 文件大小：221 K

摘要

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Summary

Objective

This study aimed to compare the levels of TB-antigen specific Interferon gamma (IFN-纬) and IFN-纬 inducible protein (IP)-10 in culture of whole blood samples from healthy controls (HC) and healthy household contacts (HHC).

Methodology

A total of 386 study subjects, which included 186 HC and 200 HHC, were recruited. QuantiFERON-TB Gold in-tube (QFT-IT) assay was employed to measure IFN-纬 levels. IP-10 levels were measured in the supernatants collected from QFT-IT tubes. Tuberculin skin test was also performed.

Results

The levels of TB antigen specific IFN-纬 and IP-10 were significantly higher in HHC compared to HC. There was no significant difference observed between positivity of QFT-IT and IP-10 in HC and HHC. The positivity of TST was significantly lower in subjects <17 year, when compared to IP-10 (p < 0.005). The reduced cut-off point 0.22 IU/ml significantly increased the positivity of QFT-IT among children with high risk for latent TB infection (LTBI).

Conclusions

Measurement of TB antigen specific IFN-纬 and IP-10 can be potential markers for the detection of LTBI.