A complementary diffusion tensor imaging (DTI)-histological study in a model of Huntington's disease
- 作者：Nadja Van Camp<sup>asup> ; Ines Blockx<sup>asup> ; Lluï ; sa Camó ; n<sup>bsup> ; Nuria de Vera<sup>bsup> ; Marleen Verhoye<sup>asup> ; Jelle Veraart<sup>csup> ; Wim Van Hecke<sup>csup> ; Emili Martí ; nez<sup>bsup> ; Guadalupe Soria<sup>bsup> ; Jan Sijbers<sup>csup> ; Anna M. Planas<sup>bsup> ; Annemie Van der Linden<sup>asup><sup> ; sup><sup>annemie.vanderlinden@ua.ac.besup>
- 关键词：Huntington's disease ; Rat model ; QUIN ; MRI ; DTI
- 刊名：Neurobiology of Aging
- 出版年：2012
- 期刊代码：202_01974580
- 类别：med
- 出版时间：May, 2012
- 卷：33
- 期：5
- 页码：945-959
- 文件大小：4197 K
摘要
In vivo diffusion tensor imaging (DTI) was performed on the quinolinic acid (QUIN) rat model of Huntington's disease, together with behavioral assessment of motor deficits and histopathological characterization. DTI and histology revealed the presence of a cortical lesion in 53%of the QUIN animals (QUIN<sup>+ctxsup>). Histologically, QUIN<sup>+ctxsup> were distinguished from QUIN<sup>鈭抍txsup> animals by increased astroglial reaction within a subregion of the caudate putamen and loss of white matter in the external capsula. Although both techniques are complementary, the quantitative character of DTI makes it possible to pick up subtle differences in tissue microstructure that are not identified with histology. DTI demonstrated differential changes of fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) in the internal and external capsula, and within a subregion of the caudate putamen. It was suggested that FA increased due to a selective loss of the subcortical connections targeted by degenerative processes at the early stage of the disease, which might turn the striatum into a seemingly more organized structure. When tissue degeneration becomes more severe, FA decreased while AD, RD and MD increased.