Continuous computation in engineered gene circuits

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• 作者：Angel Goñ ; i-Moreno ; ^{a.moreno@mmu.ac.uk} ; ^{m.amos@mmu.ac.uk} ; Martyn Amos
• 关键词：Synthetic biology ; Computer architecture ; Branch prediction
• 刊名：Biosystems
• 出版年：2012
• 期刊代码：38_03032647
• 类别：med
• 出版时间：July, 2012
• 卷：109
• 期：1
• 页码：52-56
• 文件大小：572 K

摘要

In this paper we consider the problem of representation and measurement in genetic circuits, and investigate how they can affect the reliability of engineered systems. We propose a design scheme, based on the notion of continuous computation, which addresses these issues. We illustrate the methodology by showing how a concept from computer architecture (namely, branch prediction) may be implemented in vivo, using a distributed approach. Simulation results confirm the in-principle feasibility of our method, and offer valuable insights into its future laboratory validation.