DAILY VARIATION IN AN INTENSITY OF KAOLIN - INDUCED WRITHING REACTION IN MICE

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• 作者：Sakamoto ; Koh-ichi ; Arakawa ; Masashi ; Ohmori ; Masami ; Sugimoto ; Koh-ichi ; Fujimura ; Akio
• 关键词：acute pain ; bradykinin ; icatibant ; Des-Arg⁹-[Leu⁸]-BK
• 刊名：Life Sciences
• 出版年：1997
• 期刊代码：62_00243205
• 类别：imm
• 出版时间：August 22, 1997
• 卷：61
• 期：13
• 页码：1253-1259
• 文件大小：377 K

摘要

The daily variation in an intensity of kaolin-induced writhing reaction was examined in mice kept under conditions of light; 07:00 - 19:00 and dark; 19:00 - 07:00. The number of writhes was counted for 30 minutes after a single intraperitoneal injection of kaolin at 00:00, 02:00, 04:00, 06:00, 08:00, 10:00, 12:00, 14:00, 16:00, 18:00, 20:00 and 22:00. The number of writhes showed a daily variation with a peak at 18:00 and a trough at 06:00. The intensity of writhing reaction was significantly reduced by pretreatment with the bradykinin B₁ (Des-Ar g⁹-[Leu⁸]-BK) and B₂ (icatibant) receptor antagonists. Significant daily variation in this parameter was still observed in the group with the B₁ antagonist, but disappeared in the B₂ antagonist-treated group. These results suggest that the kaolin-induced writhing reaction shows the daily variation with a peak at the end of the resting period and a trough at the end of the active period. The B₂ receptor mediated stimuli appears to be involved in this phenomenon.