Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity
- 作者：Tsukasa Baba ; Seiichi Mori ; Noriomi Matsumura ; Masatoshi Kariya ; Susan K. Murphy ; Eiji Kondoh ; Takashi Kusakari ; Hideki Kuroda ; Masaki M ; ai ; Toshihiro Higuchi ; Kenji Takakura ; Michiko N. Fukuda ; Shin
- 关键词：Ovarian cancer ; Trophinin ; Ras ; Chemosensitivity
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2007
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：24 August 2007
- 卷：360
- 期：2
- 页码：363-369
- 文件大小：443 K
摘要
Ovarian cancer is the leading cause of death in women with gynecological malignancies, with prognosis of advanced stage tumors determined by chemotherapeutic response and the success of tumor resection. Since aberrant RAS pathway activation is frequent in ovarian cancer, study of in vitro RAS-induced transformation and accompanying genomic expression changes in ovarian surface epithelial cells is imperative for development of new therapeutic modalities and for understanding tumorigenesis. cDNA microarray analysis revealed TROPHONIN (TRO), a homophilic adhesion molecule involved in blastocyst implantation, was among the genes most downregulated by RAS induction. TRO expression is higher in cisplatin-sensitive cancer cell lines and positively correlates with prognoses in ovarian cancers. TRO knockdown by RNA interference conferred cisplatin resistance and led to increased invasiveness of cultured ovarian cancer cells. These findings underscore the importance of TRO in tumorigenesis, and suggest that TRO may be a useful biomarker for cisplatin sensitivity and invasive potential.