Effects of donor age and contamination level of dioxins and related chemicals on frequency of sister chromatid exchanges in human lymphocytes cultured in vitro

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• 作者：Nagayama ; Junya ; Nagayama ; Mayumi ; Iida ; Takao ; Hirakawa ; Hironori ; Matsueda ; Takahiko ; Ohki ; Masafumi ; et. al.
• 关键词：Sister chromatid exchanges (SCEs) ; Donor age ; Polychlorinated dibenzo-p-dioxins (PCDDs) ; Polychlorinated dibenzofurans (PCDFs) ; Coplanar polychlorinated biphenyls (Co-PCBs) ; Contamination level ; Japanese people
• 刊名：Chemosphere
• 出版年：2001
• 期刊代码：15_00456535
• 类别：env
• 出版时间：May, 2001
• 卷：43
• 期：4-7
• 页码：845-849
• 文件大小：106 K

摘要

Frequencies of sister chromatid exchanges (SCEs) of human lymphocytes in control (DMSO treated) and 7,8-benzoflavone (ANF) treated cultures were measured in 39 healthy Japanese people and examined in connection with donor age. Both the control (baseline) and ANF induced SCE rates were significantly enhanced with age and highly positive correlation was observed between them. Therefore, in vivo aging seemed to have some effects on the frequencies of SCEs in human lymphocytes cultured in vitro.