Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

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• 作者：Timmer ; Mattie S.M. ; Risseeuw ; Martijn D.P. ; Verdoes ; Martijn ; Filippov ; Dmitri V. ; Plaisier ; Jasper R. ; et. al.
• 刊名：Tetrahedron ; Asymmetry
• 出版年：2005
• 期刊代码：108_09574166
• 类别：ch
• 出版时间：January 10, 2005
• 卷：16
• 期：1
• 页码：177-185
• 文件大小：244 K

摘要

By combining a Staudinger/aza-Wittig and an Ugi three-component reaction in a one-pot process (SAWU-3CR), a new and efficient multicomponent reaction was developed. The application of this reaction on readily available azido-aldehydes gave easy access to highly functionalized, enantiomerically pure pipecolic acid amides and bridged morpholine amide derivatives. The versatility of this methodology is demonstrated by the construction of a molecular library.