Discovery of small molecule leads in a biotechnology datastream

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• 作者：Gadek ; Thomas R. ; McDowell ; Robert S.
• 关键词：lead discovery ; integrin ; GPIIbIIIa ; LFA-1 ; structure activity relationship ; SAR ; protein SAR ; peptidomimetic ; Drug Discovery ; Techniques & Methods ; Pharmaceutical Science
• 刊名：Drug Discovery Today
• 出版年：2003
• 期刊代码：29_13596446
• 类别：imm
• 出版时间：June 15, 2003
• 卷：8
• 期：12
• 页码：545-550
• 文件大小：87.1 K

摘要

The traditional strengths of biotechnology research organizations (e.g. molecular biology, protein engineering, cell biology, protein expression, antibody identification and humanization) can be applied to the rational identification of small molecule leads. These efforts will augment the more traditional approaches of large pharma organizations.