Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes

详细信息	查看全文 | 推荐本文 |

• 作者：Seong Su Hong^a ; ^b ; Ji Hae Lee^a ; Wonsik Jeong^a ; ^b ; Nahyun Kim^a ; Hui Zi Jin^c ; Bang Yeon Hwang^d ; Hak-Ju Lee^e ; Sung-Joon Lee^a ; Dae Sik Jang^f ; ^{dsjang@khu.ac.kr} ; Dongho Lee^a ; ^{dongholee@korea.ac.kr}
• 关键词：Chanterelle ; Cantharellus cibarius ; Peroxisome proliferator-activated receptor (PPAR)-纬 agonist ; Acetylenic acid
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 March, 2012
• 卷：22
• 期：6
• 页码：2347-2349
• 文件大小：363 K

摘要

A new acetylenic acid, (10E,14Z)-9-oxooctadeca-10,14-dien-12-ynoic acid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E,14Z)-9-hydroxyoctadeca-10,14-dien-12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-纬 with an EC₅₀ value of 1.88 渭M as measured by a reporter gene assay. Expression of PPAR-纬 target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-纬 potential agonist that regulates transcription of the PPAR-纬 target genes.