Use of oseltamivir in Dutch nursing homes during the 2004–2005 influenza season

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• 作者：Marianne A.B. van der S ; e ; Wilhelmina L.M. Ruijs ; Adam Meijer ; Herman J.M. Cools ; Simone M. van der Plas
• 关键词：Influenza ; Nursing homes ; Oseltamivir
• 刊名：Vaccine
• 出版年：2006
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：10 November 2006
• 卷：24
• 期：44-46
• 页码：6664-6669
• 文件大小：116 K

摘要

To assess the implementation of guidelines for using neuraminidase inhibitors in the control of influenza outbreaks in Dutch nursing homes, data were collected on prophylactic and therapeutic use of anti-viral medication, indications for use and criteria for prescribing, based on experiences during the influenza season 2004–2005 in a retrospective cross-sectional survey among Dutch nursing homes after the 2004–2005 season.

Ninety/194 (49%) participating nursing homes reported an outbreak of influenza-like illness; in 57/194 (29%) influenza was laboratory confirmed. In 37/57 homes (65%) oseltamivir had been used as prophylaxis. Prophylactic use was extended to all residents and staff in 6/37 (16%) of homes, but limited in the others. In 9/37 (24%) no staff were issued prophylaxis. Among clinicians with laboratory confirmed influenza, 41/46 (89%) had used oseltamivir therapeutically. Main reasons for not prescribing oseltamivir for prophylaxis and/or therapy were lack of scientific evidence, high costs, and absent or delayed laboratory confirmation.

Logistical bottlenecks in diagnosis, cost-effectiveness concerns, and lack of an evidence-base hamper full integration in policy and should be addressed.