Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana

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• 作者：Henrik Toft Simonsen ; ^{hts@life.ku.dk}
• 关键词：Non-aromatic acetophenone ; Melicope ; Rutaceae
• 刊名：Phytochemistry Letters
• 出版年：2012
• 期刊代码：P8_18743900
• 类别：abs
• 出版时间：June, 2012
• 卷：5
• 期：2
• 页码：371-375
• 文件大小：331 K

摘要

Four novel geminally dialkylated, non-aromatic acetophenone derivatives ass="boldFont">1-ass="boldFont">4 were isolated from Melicope coodeana. The compounds, related to hop bitter acids, were named Coodeanones A-C, where Coodeanone B was found in both E and Z configuration of the 6鈥测€粹€?鈥测€?double bond. Antibacterial, antifungal and antimalarial activities of the acetophenone derivaties were investigated, and Coodeanone C (ass="boldFont">4) was found to have activity toward Plasmodium falciparum (malaria) (IC₅₀ = 42.8 渭M).