Cytotoxic activity of five limonoids from Meliae cortex and their structure-activity relationship

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• 作者：Zhi-Peng DENG^螖 ; Shao-Chao LIU^螖 ; Shu-Xiang CUI ; Ling ZHOU ; Qing-Qiang YAO ; ^{yqingqiang@yahoo.com}
• 关键词：Limonoids ; Meliae cortex ; Cytotoxic activity ; Structure-activity relation
• 刊名：Chinese Journal of Natural Medicines
• 出版年：2012
• 期刊代码：P72_18755364
• 类别：med
• 出版时间：May, 2012
• 卷：10
• 期：3
• 页码：238-240
• 文件大小：160 K

摘要

ass="h4">Aim

To investigate the cytotoxic activity of five limonoids (ass="boldFont">1-ass="boldFont">5) and illuminate their structure-activity relationship (SAR).

ass="h4">Methods

Compounds ass="boldFont">1-ass="boldFont">5 isolated from Meliae cortex were examined for their cytotoxic activity against three cancer cell lines in vitro by MTT method.

ass="h4">Results

Among the tested compounds, all compounds possessed their potent antitumor activity. Especially compound ass="boldFont">1 was the most active compound against human liver cancer BEL7402 cells (IC₅₀ 8.57 渭g路mL^鈭?), human lung cancer H460 cells (IC₅₀ 6.29 渭g路mL^鈭?), human stomach cancer SGC-7901 cells (IC₅₀ 6.08 渭g路mL^鈭?).

ass="h4">Conclusion

The SAR of compounds ass="boldFont">1-ass="boldFont">5 indicated that 16-OH was very important for keeping the cytotoxic activity of limonoids.