SAR of a novel ‘Anthranilamide Like’ series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer
- 作者：Philip Wickens ; Harold Kluender ; Julie Dixon ; Catherine Brennan ; Furahi Achebe ; Antonella Bacchiocchi ; Don Bankston ; Donald Bierer ; Michael Br ; s ; Debbie Braun ; Melissa S. Brown ; Chih-Yuan Chuang ; Jacq
- 关键词：Kinase ; Cancer ; Anthranilamide
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：1 August 2007
- 卷：17
- 期：15
- 页码：4378-4381
- 文件大小：189 K
摘要
Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active.