Insights from honeybee (Apis mellifera) and fly (Drosophila melanogaster) nicotinic acetylcholine receptors: From genes to behavioral functions

详细信息	查看全文 | 推荐本文 |

• 作者：Julien Dupuis^a ; ^b ; ¹ ; Thierry Louis^a ; ^b ; Monique Gauthier^a ; ^b ; ^{gauthiem@cict.fr} ; Valé ; rie Raymond^a ; ^b
• 关键词：Insects ; Drosophila ; Honeybee ; Acetylcholine ; Nicotinic-acetylcholine receptors ; Insect genome sequencing ; 伪 subunit ; 尾 subunit ; Nicotinic-acetylcholine receptor molecular structure ; Kenyon cell ; Vertical lobe ; 伪-Bungarotoxin ; Mecamylamine ; Insect beha
• 刊名：Neuroscience and Biobehavioral Reviews
• 出版年：2012
• 期刊代码：61_01497634
• 类别：psy
• 出版时间：July, 2012
• 卷：36
• 期：6
• 页码：1553-1564
• 文件大小：1195 K

摘要

Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system of insects where they supply fast synaptic excitatory transmission and represent a major target for several insecticides. The unbalance is striking between the abundant literature on nAChR sensitivity to insecticides and the rarity of information regarding their molecular properties and cognitive functions. The recent advent of genome sequencing disclosed that nAChR gene families of insects are rather small-sized compared to vertebrates. Behavioral experiments performed in the honeybee demonstrated that a subpopulation of nAChRs sensitive to the venom 伪-bungarotoxin and permeant to calcium is necessary for the formation of long-term memory. Concomitant data in Drosophila reported that repetitive exposure to nicotine results in a calcium-dependent plasticity of the nAChR-mediated response involving cAMP signaling cascades and indicated that ACh-induced Ca⁺⁺ currents are modulated by monoamines involved in aversive and appetitive learning. As in vertebrates, in which glutamate and NMDA-type glutamate receptors are involved in experience-associated synaptic plasticity and memory formation, insects could display a comparable system based on ACh and 伪-Bgt-sensitive nAChRs.