Testosterone pellet implants and migraine headaches: A pilot study

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• 作者：Rebecca Glaser^a ; ^b ; ^{rglaser@woh.rr.com} ; ^{rglasermd@gmail.com} ; Constantine Dimitrakakis^c ; ^d ; ^{dimitrac@mail.nih.gov} ; Nancy Trimble^e ; ^{ntrimble@woh.rr.com} ; Vincent Martin^f ; ^{martinvt@ucmail.uc.edu}
• 关键词：Androgens ; Testosterone ; Implant ; Migraine headache ; Pre-menopausal ; Post-menopausal
• 刊名：Maturitas
• 出版年：2012
• 期刊代码：192_03785122
• 类别：med
• 出版时间：April, 2012
• 卷：71
• 期：4
• 页码：385-388
• 文件大小：132 K

摘要

The purpose of this prospective pilot study was to determine the therapeutic effect of continuous testosterone, delivered as a subcutaneous implant, on the severity of migraine headaches in pre- and post-menopausal patients. Twenty-seven women with a history of documented migraine headache were asked to rate their headache severity using a five-point scale at baseline (prior to therapy); and again, 3 months following treatment with testosterone implants. Improvement in headache severity was noted by 92%of patients and the mean level of improvement was statistically significant (3.3 on a 5 point scale). In addition, there was no difference in the level of improvement between pre- and post-menopausal cohorts. Seventy-four percent of patients reported a headache severity score of 鈥?鈥?(none) on testosterone implant therapy for the 3-month treatment period. Continuous testosterone was effective therapy in reducing the severity of migraine headaches in both pre- and post-menopausal women.