Tissue inhibitor of metalloproteinases in oral squamous cell carcinomas - A therapeutic target?

详细信息	查看全文 | 推荐本文 |

• 作者：Mario Pé ; rez-Sayá ; ns Garcí ; a^a ; ^e ; ^{perezsayans@gmail.com} ; José ; Manuel Suá ; rez-Peñ ; aranda^b ; ^{jm.suarez.penaranda@gmail.com} ; Pilar Gayoso-Diz^c ; ^{pilar.gayoso.diz@sergas.es} ; Francisco Barros-Angueira^d ; ¹ ; ^{francisco.barros@usc.es} ; José ; Manuel Gá ; ndara-Rey^e ; ² ; ^{josemanuel.gandara@usc.es} ; Abel Garcí ; a-Garcí ; a^a ; ^e ; ³ ; ^{abel.garcia@usc.es}
• 关键词：Matrix metalloproteinases (MMPs) ; Tissue inhibitors of metalloproteinases (TIMPs) ; Metalloproteinases inhibitors (MMIs) ; Oral squamous cell carcinomas (OSCC)
• 刊名：Cancer Letters
• 出版年：2012
• 期刊代码：44_03043835
• 类别：med
• 出版时间：1 October, 2012
• 卷：323
• 期：1
• 页码：11-19
• 文件大小：357 K

摘要

Matrix metalloproteinases (MMPs) are proteases responsible for remodeling the extracellular matrix (ECM) and enabling spreading and metastasis of tumor cells, a common phenomenon in oral squamous cell carcinomas (OSCC). They are strongly blocked by several inhibitors, among which we must highlight, for their specificity and potency, the endogenous tissue inhibitors of metalloproteinases (TIMP-1, -2, -3 and -4). The goal of this paper is to describe the expression of TIMPs in OSCC, determining their relation with clinical, histological and prognostic factors, delving into OSCC regulation mechanisms and discussing the use of exogenous TIMPs to treat this type of tumors. Expression of TIMPs in OSCC is higher in tumors than in normal tissue, which correlates with an increase of metastatic risk and regional lymph node affectation. Although some metalloproteinases inhibitors (MMIs) have shown promising results in the treatment of these tumors, their use in OSCC has not been widely tested; and although some indirect MMIs, like COX-2 inhibitors, flavonoids and endostatin seem to have beneficial effects on the invasive capacity of OSCC through regulation of MMPs and TIMP levels, routine clinical use has not been accepted yet.