• 作者：L. Mé ; rida Rodrigo^a ; ^{luismr@hcs.es} ; V. Faus Felipe^b ; F. Poveda Gó ; mez^a ; J. Garcí ; a Alegrí ; a^a
• 关键词：Agranulocitosis ; Metamizol
• 刊名：Revista Cl铆nica Espa帽ola
• 出版年：2009
• 期刊代码：pca307_00142565
• 类别：med
• 出版时间：April 2009
• 卷：209
• 期：4
• 页码：176-179
• 文件大小：277 K

Objective

Analyze the clinical and epidemiological features of this adverse effect and assess its incidence in the general population, especially in the British one.

Methods

A descriptive, retrospective analysis of all the patients discharged at Hospital Costa del Sol (Marbella) with a main diagnosis of dipyrone-related agranulocytosis in the Minimum Basic Data Set (MBDS) from January 1998 to December 2003. Neutropenia was defined as severe (neutrophils lower than 500/ml), moderate (500-1000/ml) and mild (1000-1500/ml).

Results

13 patients developed dipyrone-related agranulocytosis, 8 of them foreign (61.5%) and 5 from United Kingdom. The rate of events was 8.33/106 inhabitants/year. With regard to British population registered in the area, the estimated rate of events was 20.4 cases/106 inhabitants/year.

Conclusion

Dipyrone-related agranulocytosis is an adverse effect more frequent in British population, and its use must be avoided.