Synthesis of trifluoromethylated pyrazoles from trifluoromethylenaminones and monosubstituted hydrazines

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• 作者：Touzot ; Aline ; Soufyane ; Mustapha ; Berber ; Hatice ; Toupet ; Loï ; c ; Mirand ; Catherine
• 关键词：β ; -Enaminotrifluoromethylketones ; Phenylhydrazine ; Methylhydrazine ; Trifluoromethyl-1H-pyrazoles
• 刊名：Journal of Fluorine Chemistry
• 出版年：2004
• 期刊代码：52_00221139
• 类别：ch
• 出版时间：September, 2004
• 卷：125
• 期：9
• 页码：1299-1304
• 文件大小：185 K

摘要

Cyclocondensation of monosubstituted hydrazines 2a–c with trifluoromethylenaminones 1a–c afforded 3-CF₃ and (or) 5-CF₃ pyrazoles 3–6. Addition of N-methylhydrazine to enaminone led to 3-CF₃ pyrazole as the major product, whereas phenylhydrazine gave regiospecific formation of 5-CF₃ pyrazole.