GM1 ganglioside attenuates convulsions and thiobarbituric acid reactive substances production induced by the intrastriatal injection of methylmalonic acid
- 作者：Fighera ; Michele Rechia ; Bonini ; Juliana Sartori ; de Oliveira ; Telma Grendene ; Frussa-Filho ; Roberto ; et. al.
- 关键词：TBARS ; thiobarbituric acid reactive substances ; GM1 ; monosialoganglioside ; NMDA ; N-methyl-d-aspartate ; MDA ; malondialdehyde ; CNS ; central nervous system ; l-Methylmalonic acid ; Convulsion ; Monosialoganglioside ; Thiobarbituric acid reactive substances ; Asco
- 刊名：The International Journal of Biochemistry and Cell Biology
- 出版年：2003
- 期刊代码：127_13572725
- 类别：med
- 出版时间：April, 2003
- 卷：35
- 期：4
- 页码：465-473
- 文件大小：137 K
摘要
The effects of the administration of monosialoganglioside (GM1) on methylmalonic acid (MMA)-induced convulsions, production of thiobarbituric acid reactive substances (TBARS) and on the striatal content of ascorbic acid and total non-protein thiol (SH) groups were evaluated in adult male rats. Animals received two intraperitoneal injections of GM1 (50mg/kg) or saline (0.85%NaCl) spaced 24h apart. Thirty minutes after the second GM1 or saline injection, l-MMA (6μmol) or NaCl (9μmol) was injected into the right striatum and the animals were observed for the appearance of convulsions for 15min. The animals were sacrificed and their striatal content of ascorbic acid, SH groups and TBARS was measured. The effect of GM1 on MMA-induced TBARS production in striatal homogenates was also evaluated in vitro.