The pharmacokinetics of the prostaglandin E1 analogue misoprostol in plasma and colostrum after postpartum oral administration
- 作者：Abdel-Aleem ; Hany ; Villar ; José ; Metin Gü ; lmezoglu ; A. ; Mostafa ; Sayed A. ; Youssef ; Alaa A. ; et. al.
- 关键词：Oral misoprostol ; Postpartum ; Pharmacokinetics ; Colostrum
- 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
- 出版年：2003
- 期刊代码：92_03012115
- 类别：med
- 出版时间：May 1, 2003
- 卷：108
- 期：1
- 页码：25-28
- 文件大小：94.7 K
摘要
Objective: To study pharmacokinetics of prostaglandin E1 analogue, misoprostol in plasma and colostrum after postpartum oral administration. Study design: Twenty women received 600μg doses of misoprostol orally after delivery. Plasma levels of the principal metabolite, misoprostol acid, were measured at 2, 10, 20, 30, 40, 50, 60, 90, 120, 180, 240 and 300min (48 samples). Colostrum was expressed from the breasts to measure misoprostol acid at 60, 120, 180, 240, and 300min (24 samples). Assay was done using isotope dilution gas chromatography (GC)/negative ion chemical ionisation mass spectrometry (MS). Results: The plasma concentration of misoprostol acid rose quickly. Two minutes after oral administration its mean level was 91.5pg/ml, peaked at 20min (344pg/ml), then fell steeply by 120min (27.8pg/ml) and remained low for the duration of the study. Misoprostol acid in colostrum reached maximum concentration of 20.9pg/m within 1h after oral administration. It then declined gradually to 17.8pg/ml at 2h, 2.8pg/ml at 4h and to <1pg/ml at 5h. Areas under misoprostol concentration versus time curves up to 5h were 290.1pgh/ml in the plasma and 51.4pgh/ml in colostrum, respectively. Conclusion: Misoprostol acid is secreted in colostrum within 1h of oral administration of 600μg of misoprostol; the pharmacokinetics of misoprostol after oral administration during postpartum is similar to that of other pregnancy periods.