Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1

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• 作者：Sun-Don Kim^a ; Jia Lie Liu^a ; Tony Roscioli^b ; Michael F. Buckley^c ; Garima Yagnik^a ; Simeon A. Boyadjiev^a ; ^{simeon.boyd@ucdmc.ucdavis.edu} ; Jinoh Kim^a ; ^{jinoh.kim@ucdmc.ucdavis.edu}
• 关键词：Craniofacial development ; ER export ; FGFR regulation ; FGF-signaling ; Non-syndromic craniosynostosis
• 出版年：2012
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：21 May, 2012
• 卷：586
• 期：10
• 页码：1516-1521
• 文件大小：1035 K

摘要

Fibroblast growth factor receptors (FGFRs) play critical roles in craniofacial and skeletal development via multiple signaling pathways including MAPK, PI3K/AKT, and PLC-纬. FGFR-mediated signaling is modulated by several regulators. Proteins with leucine-rich repeat (LRR) and/or immunoglobulin (IG) superfamily domains have been suggested to interact with FGFRs. In addition, fibronectin leucine-rich repeat transmembrane protein 3 (FLRT3) has been shown to modulate the FGFR-mediated signaling via the fibronectin type III (FNIII) domain. Therefore proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs.