摘要
Organocatalytic asymmetric Michael addition of 3-(OTBS)-propanal to 尾-nitrostyrenes catalyzed by chiral sulfamides was investigated. Good d.r. (up to 80:20) and excellent enantioselectivities (up to >99%ee) were achieved. Both the N-[(1R,2R)-2-aminocyclohexyl]-N鈥?(phenylmethyl)sulfamide 7b and the novel chiral N-[(1R,2R)-2-aminocyclohexyl]-N鈥?[3,5-bis(trifluoromethyl)phenyl]sulfamide 7a were identified as efficient primary amine organocatalysts.