Augmentation of central arterial pressure as a marker of atherosclerosis in patients with type 2 diabetes
- 作者：Fukui ; Michiaki ; Kitagawa ; Yoshihiro ; Nakamura ; Naoto ; Mogami ; Shinichi ; Ohnishi ; Masayoshi ; et. al.
- 关键词：Type 2 diabetes ; Atherosclerosis ; Augmentation
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2003
- 期刊代码：78_01688227
- 类别：med
- 出版时间：February, 2003
- 卷：59
- 期：2
- 页码：153-161
- 文件大小：240 K
摘要
Macrovascular disease is the most common cause of morbidity and mortality in diabetic patients. With the increasing numbers of patients with type 2 diabetes, a simple, noninvasive method is needed to detect atherosclerosis. Augmentation represents the difference between the second and first peaks of the central arterial pressure waveform in systole and is a measure of systemic arterial stiffness, which causes the pressure wave to rebound. We investigated whether augmentation could serve as a marker of atherosclerosis in patients with type 2 diabetes. Central arterial pressure and degree of its augmentation by pulse wave rebound were measured sphygmographically in 208 consecutive patients with type 2 diabetes and 117 healthy control subjects. The relationship between augmentation and carotid atherosclerosis detected by carotid ultrasonography was investigated in a subgroup of 81 diabetic patients. Augmentation was greater in diabetic patients than control subjects (13.2±6.9 vs. 9.4±5.7 mm Hg, P<0.0001). The positive correlation between augmentation and intima-media thickness (r