MK-801 inhibits the micturition reflex in chronic bladder irritation caused by crystalluria in the rat
- 作者：Ishida ; Fumitaka ; Sato ; Tomoya ; Imaizumi ; Michiru ; Funayama ; Norio ; Ikegami ; Kenji ; Nimura ; Toshie ; et. al.
- 关键词：Chronic cystitis ; Micturition reflex ; Crystalluria ; NMDA ; MK-801 ; Visceral pain ; Urinary bladder
- 刊名：Autonomic Neuroscience
- 出版年：2003
- 期刊代码：31_15660702
- 类别：med
- 出版时间：April 30, 2003
- 卷：105
- 期：1
- 页码：1-7
- 文件大小：224 K
摘要
Urodynamic and pharmacological studies were performed to investigate the effect of crystalluria on the micturition reflex and the involvement of glutamatergic transmission. The rats, which were given LP-805 (100 mg/kg/day) orally for 12 days, voided crystalluria. The pH of these crystalluria (LP-805 urine) was the same as normal urine. The amount of crystals was 70–100/division magnified 400×. The end of the crystals was sharp. Intravesical administration of LP-805 urine induced hyperreflexia of the micturition reflex in normal rats. When the infusion solution was changed to LP-805 urine from saline, the latency was reduced to 57.6±2.1%of control in single cystometrogram (CMG) or was reduced to 51.4±0.9%of control in continuous CMG. The voiding volume was reduced to 52.1±3.6%of control in single CMG or was reduced to 62.5±0.8%of control in continuous CMG. These parameters were recovered after LP-805 urine was removed. Intravesical administration of acetic acid did not induce hyperreflexia of the micturition reflex in LP-805-treated rats. These data suggest that the chronic irritation by aculeate crystals might induce hyperreflexia of the micturition reflex, which increase afferent neuronal activity.