Quantitative characterization of the electrospun gelatin-chitosan nanofibers by coupling scanning electron microscopy and atomic force microscopy

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• 作者：Shilu Wang^a ; ^b ; Guoming Zhao^a ; ^{zhaogm@qibebt.ac.cn}
• 关键词：Electrospinning ; Gelatin&ndash ; chitosan nanofibers ; Atomic force microscopy ; HarmoniX ; Elastic properties ; DMT modulus
• 刊名：Materials Letters
• 出版年：2012
• 期刊代码：59_0167577x
• 类别：ms
• 出版时间：15 July, 2012
• 卷：79
• 期：Complete
• 页码：14-17
• 文件大小：706 K

摘要

Nanofibers were electrospun from gelatin and chitosan at different mass ratios (gelatin/chitosan: 0/100, 25/75, 50/50, 75/25, 100/0). Atomic force microscopy (AFM) combined with scanning electron microscopy (SEM) was utilized in this study to evaluate the morphological and mechanical properties of the gelatin-chitosan nanofibers. The SEM images showed that the electrospun gelatin-chitosan nanofibers possessed more uniform morphologies than the pure gelatin or chitosan nanofibers. Moreover, AFM-HarmoniX mode was used to quantitatively assess the Derjaguin-M眉ller-Toporov (DMT) modulus of gelatin-chitosan nanofibers. After modified by two correction factors, the DMT modulus of gelatin-chitosan nanofibers showed higher values than the pure gelatin or chitosan nanofibers, which indicated the existence of intermolecular interaction within the electrospun gelatin-chitosan nanofibers.