Hydra, a niche for cell and developmental plasticity
- 作者：Brigitte Galliot ; Marijana Miljkovic-Licina ; Renaud de Rosa and Simona Chera
- 关键词：Cytoprotection ; Serine-protease inhibitor Kazal1 ; Blastema transition ; CREB pathway ; paraHox Gsx/cnox-2 gene
- 刊名：Seminars in Cell and Developmental Biology
- 出版年：2006
- 期刊代码：186_10849521
- 类别：bio
- 出版时间：August 2006
- 卷：17
- 期：4
- 页码：492-502
- 文件大小：774 K
摘要
The silencing of genes whose expression is restricted to specific cell types and/or specific regeneration stages opens avenues to decipher the molecular control of the cellular plasticity underlying head regeneration in hydra. In this review, we highlight recent studies that identified genes involved in the immediate cytoprotective function played by gland cells after amputation; the early dedifferentiation of digestive cells into blastema-like cells during head regeneration, and the early late proliferation of neuronal progenitors required for head patterning. Hence, developmental plasticity in hydra relies on spatially restricted and timely orchestrated cellular modifications, where the functions played by stem cells remain to be characterized.