Spatial working memory dysfunction in minimal hepatic encephalopathy: An ethology and BOLD-fMRI study

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• 作者：Ling-min Liao^a ; ^b ; ^c ; Li-xue Zhou^c ; Hong-bo Le^a ; ^b ; Jing-jing Yin^a ; ^b ; Shu-hua Ma^a ; ^b ; ^d ; ^{lingmin.liao@gmail.com}
• 关键词：MHE ; minimal hepatic encephalopathy ; HE ; hepatic encephalopathy ; NCT-A ; number connection test A ; DST ; digit symbol test ; WMS-CR ; Wechsler Memory scale&mdash ; Chinese revised ; PFC ; prefrontal cortex ; PreMA ; premotor areas ; SMA ; supplementary motor area ; PA
• 刊名：Brain Research
• 出版年：2012
• 期刊代码：8_00068993
• 类别：neu
• 出版时间：22 March, 2012
• 卷：1445
• 期：Complete
• 页码：62-72
• 文件大小：810 K

摘要

The term 鈥渕inimal hepatic encephalopathy鈥?(MHE) refers to a population of individuals who have no recognizable clinical symptoms but perform abnormally on neuropsychological and neurophysiological tests. Research shows that MHE patients have impairments in cognition affecting their daily lives that should be treated. This study explored the neural basis of spatial working memory impairment in MHE patients using behavioral test and BOLD-fMRI. Twelve normal controls, twelve cirrhosis patients without MHE and twelve MHE patients took part. The memory quotient of the MHE group (Wechsler Memory Scale鈥擟hinese revised: WMS-CR) was lower than the normal control group and the cirrhosis-without-MHE group, and primarily concerned short-term memory and transient memory. Performance accuracy was lower for the MHE group than the control group and the cirrhosis-without-MHE group, and mean reaction time was prolonged. The fMRI data highlighted a neural network consisting of: bilateral prefrontal cortex (PFC), bilateral premotor area (PreMA), supplementary motor area (SMA) and bilateral parietal areas (PA), which was activated in the n-back task. The load effect of BOLD-fMRI response appeared in all regions of interest (ROI) for the normal control group, but only appeared in PreMA and PA, and did not vary with n-back load in PFC or SMA for the MHE group. Activation intensities for all ROIs were higher for the normal control group than the MHE group, especially in 2-back load. In conclusion, these results demonstrate that MHE patients have debilitated spatial working memory, and that impairments of bilateral PFC, PMA, SMA, and PA commonly lead to spatial working memory dysfunction. Furthermore, PFC impairment may form the neural basis of spatial working memory impairment.