A STR mutation in a heteropaternal twin case

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• 作者：Geada ; Helena ; Ribeiro ; Teresa ; Brito ; Rui M. ; Espinheira ; Rosa ; Rolf ; Burkhard ; Hohoff ; Carsten ; et. al.
• 关键词：Paternity investigation ; Heteropaternal twins ; Minisatellites ; Short tandem repeats ; ACTBP2 mutation
• 刊名：Forensic Science International
• 出版年：2001
• 期刊代码：104_03790738
• 类别：med
• 出版时间：December 1, 2001
• 卷：123
• 期：2-3
• 页码：239-242
• 文件大小：62.9 K

摘要

A heteropaternal male twin case with two men being alleged fathers was investigated as requested by the Court. Up to 37 PCR-based polymorphic DNA systems were studied in this case which was complicated by a paternal ACTBP2 mutation detected in one twin. This is the first report on a STR mutation in a double paternity case where both biological fathers were indisputably identified. The STR systems enable the resolution of these complex genetic relationships even in a case where a mutation in one STR locus was encountered.