The population structure of the Cryptosporidium parvum population in Scotland: A complex picture
- 作者：Liam J. Morrison ; Marianne E. Mallon ; Huw V. Smith ; Annette MacLeod ; Lihua Xiao ; Andy Tait
- 关键词：Cryptosporidium parvum ; Population genetics ; Microsatellite repeats ; Minisatellite repeats ; Genotype
- 刊名：Infection ; Genetics and Evolution
- 出版年：2008
- 期刊代码：119_15671348
- 类别：med
- 出版时间：March 2008
- 卷：8
- 期：2
- 页码：121-129
- 文件大小：330 K
摘要
We genotyped 297 Scottish C. parvum samples using micro- and minisatellites. Treated as a single population, the population structure was epidemic. When regional populations were analysed, there was evidence of sub-population structure variations. This was dependent upon excluding sub-groups exhibiting significant genetic distance from the main population, implying genetic sub-structuring. We tested the hypothesis that these sub-groups originated outside the UK and demonstrated that one sub-group clustered with Peruvian samples. A geographically comprehensive panel of isolates would fully confirm this result. These data indicate limited sub-structuring within a small geographical area, but substantial sub-structuring over larger geographical distances. Host movement influences parasite diversity and population structure, evidenced by strong correlation (r2 = 0.9686) between cattle movements and parasite diversity. Thus, the population structure of C. parvum is complex, with sub-populations differing in structure and being influenced by host movements, including the introduction of novel multilocus genotypes from geographically distinct regions.