Results of a collaborative study of the EDNAP group regarding mitochondrial DNA heteroplasmy and segregation in hair shafts
- 作者：Tully ; G. ; Barritt ; S.M. ; Bender ; K. ; Brignon ; E. ; Capelli ; C. ; Dimo-Simonin ; N. ; Eichmann ; C. ; et. al.
- 关键词：Mitochondrial DNA ; Heteroplasmy ; Mutation ; Segregation ; Hair
- 刊名：Forensic Science International
- 出版年：2004
- 期刊代码：104_03790738
- 类别：med
- 出版时间：February 10, 2004
- 卷：140
- 期：1
- 页码：1-11
- 文件大小：494 K
摘要
A collaborative exercise was carried out by the European DNA Profiling Group (EDNAP) in order to evaluate the distribution of mitochondrial DNA (mtDNA) heteroplasmy amongst the hairs of an individual who displays point heteroplasmy in blood and buccal cells. A second aim of the exercise was to study reproducibility of mtDNA sequencing of hairs between laboratories using differing chemistries, further to the first mtDNA reproducibility study carried out by the EDNAP group [Forensic Sci. Int. 97 (1998) 165]. Laboratories were asked to type 2 sections from each of 10 hairs, such that each hair was typed by at least two laboratories. Ten laboratories participated in the study, and a total of 55 hairs were typed.