This paper reviews the field of computational mechanobiology with focus on bone healing. The history of mechanoregulatory modeling is described, as well as the recent advances and current problems. Most recent advances have been focusing on integrating the mechano-regulatory algorithms with more sophisticated description of the cellular and molecular events. Achieving suitable validation for the models is the most significant challenge. Thus far, focus has been on corroborating mechanoregulatory models by comparing existing models with well characterized experimental data, identify shortcomings and further develop improved computational models of bone healing. Ultimately, these models can be used to help unraveling the basic principles of cell and tissue differentiation, optimization of implant design, and potentially to investigate treatments of non-union and other pathologies.