The pentafluorophenyl group as a module for the direct modification of chiral diamines for asymmetric catalysis

详细信息	查看全文 | 推荐本文 |

• 作者：Toshinobu Korenaga ; Kenji Nomura ; Shinichi Minami ; Hitomi Sasaki ; Takashi Sakai
• 关键词：Web ; Ruby ; Ruby on rails ; AJAX ; Analysis code ; Super computer
• 刊名：Tetrahedron ; Asymmetry
• 出版年：2008
• 期刊代码：108_09574166
• 类别：ch
• 出版时间：3 April 2008
• 卷：19
• 期：6
• 页码：695-700
• 文件大小：155 K

摘要

A pentafluorophenyl group embedded in a chiral diamine allows the direct modification of an aryl group. The diamine is readily converted into para-disubstituted diamines. Although the electronic effect of the modified diamine somewhat lowers the catalytic activity of BINAP–Ru–diamine-catalyzed asymmetric hydrogenation, the enantioselectivity of the product is higher than that obtained by using a typical chiral diamine. Such an easy and direct modification of the chiral ligand has the potential to facilitate the optimization of the steric effect of chiral ligands in asymmetric catalysis.