Sedative, antiepileptic and antipsychotic effects of Viscum album L. (Loranthaceae) in mice and rats

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• 作者：Gaurav Gupta^a ; Imran Kazmi^a ; Muhammad Afzal^a ; Mahfoozur Rahman^b ; Shakir Saleem^c ; Md. Shamim Ashraf^c ; Mohammad Javed Khusroo^c ; Khalid Nazeer^d ; Sayeed Ahmed^c ; Mohd Mujeeb^a ; Zubair Ahmed^c ; Firoz Anwar^a ; ^{firoz_anwar2000@yahoo.com}
• 关键词：Viscum album L. ; Sedative ; Antiepileptic ; Antipsychotic ; GABA ; Rodents
• 刊名：Journal of Ethnopharmacology
• 出版年：2012
• 期刊代码：26_03788741
• 类别：pha
• 出版时间：14 June, 2012
• 卷：141
• 期：3
• 页码：810-816
• 文件大小：379 K

摘要

Ethnopharmacological relevance

Viscum album L. is claimed in traditional medical practice, to be useful in the treatment of epilepsy and insomnia in Himachal Pradesh, India.

Materials and methods

The effect of Viscum album L. on epilepsy, psychosis and sedative activity was evaluated in mice and rats using standard procedure.

Results

The aqueous leaf extract of Viscum album L. prolonged the pentobarbital induced sleeping time and reduced the locomotor activity in actophotometer. This suggests that reduced locomotor activity facilitate GABAergic transmission. In addition the extract reduced MES, INH and PTZ-induced convulsions which suggest that there may be possibility of blocking Na⁺ channels, opening of Cl^{鈭?/sup>channels or enhancing the GABAergic system. The extract decreased the apomorphine-induced stereotyped behavior and potentiates the HAL-induced cataleptic score which suggests the extract possess antidopaminergic activity.}

Conclusion

The results obtained in present study suggested that title plant exhibited sedative, antiepileptic and antipsychotic activity in mice and rats.