In聽vivo uses of aptamers selected against cell surface biomarkers for therapy and molecular imaging

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• 作者：Agnes Cibiel^a ; ^b ; ^c ; Carine Pestourie^a ; ^b ; ^c ; Fré ; dé ; ric Ducongé ; ^a ; ^b ; ^c ; ^{frederic.duconge@cea.fr}
• 关键词：Aptamers ; Cell surface biomarkers ; Molecular imaging ; Therapy
• 刊名：Biochimie
• 出版年：2012
• 期刊代码：24_03009084
• 类别：bio
• 出版时间：July, 2012
• 卷：94
• 期：7
• 页码：1595-1606
• 文件大小：472 K

摘要

Nucleic acid Aptamers are ligands that are selected by a process of molecular evolution to bind with high affinities and specificities to a specific target. Recently, an increasing number of aptamers have been selected against biomarkers expressed at the surface of human cells or infectious pathogens. This class of targets, mostly proteins, is associated with several pathologies including cancer, inflammation and infection diseases. Several of these cell surface specific aptamers were tested in聽vivo as drugs or as targeting agents for nanocarriers, siRNA or contrast agents. Strikingly, they were used to develop a wide variety of new treatments or new approaches for molecular imaging and they were also able to improve current therapies such as chemotherapy, radiotherapy or immunotherapy. This review presents these different applications and the different studies conducted in聽vivo with this class of aptamers, predominantly in pre-clinical models.