• 作者：Marta Simarro Rueda^a ; ^{martasimr@gmail.com} ; Julio A. Carbayo Herencia^b ; Javier Massó ; Orozco^c ; Luis Miguel Artigao Rodenas^d ; Lucinio Carrió ; n Valero^e ; Juan Antonio Divisó ; n Garrote^e ; Pilar Torres Moreno^e ; Juan Ló ; pez Abril^d ; Abel J. Herrero Herná ; ndez^f ; Francisca Molina Escribano^g ; en nombre del Grupo de Enfermedades Vasculares de Albacete (GEVA)
• 关键词：Obesidad abdominal ; Resistencia a la insulina ; Factores de riesgo cardiovascular
• 刊名：Endocrinolog铆a y Nutrici贸n
• 出版年：2011
• 期刊代码：pca151_15750922
• 类别：med
• 出版时间：November 2011
• 卷：58
• 期：9
• 页码：464-471
• 文件大小：165 K

Background and Objective

Insulin resistance (IR) has been directly related to obesity, particularly central obesity, and to other cardiovascular risk factors (CVRFs). Direct IR quantification is difficult in clinical practice, and indirect methods such as HOMA (homeostasis model assessment) have therefore been developed. The aim of this study was to assess the association of IR, as measured by HOMA, with different anthropometric measures and some CVRFs.

Materials and Methods

A cross-sectional, observational study was carried out in a general population sample older than 18 years in the province of Albacete, Spain. Sample size was 678 subjects. Participants completed a survey and underwent physical examinations and laboratory tests. Obesity measures included body mass index, waist perimeter, and sagittal abdominal diameter. Data analysis was performed using SPSS 15.0 software.

Results

Mean values of obesity measures were higher in males as compared to females and increased with age. IR prevalence was 39.8%. All assessed anthropometric measures, decreased HDL (high density lipoprotein) cholesterol and increased non-HDL cholesterol were independently associated to the risk of IR.

Conclusions

A clear association exists between different anthropometrical measures and IR in the general population. There is also an association between lipid profile cahnges and the risk of experiencing IR.