We enrolled 366 patients from the district of Marburg-Biedenkopf and calculated annual epilepsy-specific costs of 鈧?738 per patient. Direct costs contributed 31.1%(鈧?406) and indirect costs 68.9%(鈧?332) of the total costs. Direct medical costs were mainly due to hospitalization (33.2%of total direct costs) and anticonvulsants (26.7%). Costs of admissions were due to status epilepticus (24.4%), video-EEG monitoring (14.8%), newly diagnosed patients (14.4%) and seizure-related injuries (8.8%). Indirect costs were mainly due to early retirement (38.0%), unemployment (35.9%) and days off due to seizures (26.2%). The mean costs of epilepsy found in our study were lower than those found in studies conducted at European epilepsy centers due to the inclusion of patients in all health-care sectors.