• 作者：J.M. Martí ; n^a ; ^{Martin.josemaria@gmail.com} ; M. Rubio^a ; R. Bella^a ; E. Jordá ; ^a ; ^c ; C. Monteagudo^b ; ^c
• 关键词：Halo nevo ; Nevo melanoc&iacute ; tico ; Melanoma ; Regresi&oacute ; n
• 刊名：Actas Dermo-Sifiliogr谩ficas
• 出版年：2012
• 期刊代码：pca35_00017310
• 类别：med
• 出版时间：June, 2012
• 卷：103
• 期：5
• 页码：401-410
• 文件大小：1598 K

class="h4">Background

The complete regression of melanocytic tumors, confirmed by histology, has rarely been reported in the literature. It is very difficult to determine the malignant or benign nature of a regressed tumor, and on occasions, the only indication of malignancy is the subsequent development of metastasis.

class="h4">Material and methods

We performed a descriptive study of melanocytic nevi that had undergone complete, histologically confirmed regression prior to excision in the dermatology department of our hospital over a period of 3 years. We included only lesions in which dermoscopy performed prior to regression showed features that suggested benignity. We assessed various clinical, dermoscopic, histologic, and immunohistochemical features.

class="h4">Results

The mean time to complete regression was 6.4 months. The main dermoscopic patterns observed were reticular and mixed reticular/globular. Unlike what is generally seen in melanomas, the main histologic finding was the presence of fine or lamellar fibrosis. In all cases, there was a predominance of CD8⁺ T cells.

class="h4">Conclusions

The clinical, dermoscopic, and histologic features of the melanocytic nevi studied suggest the existence of a highly characteristic form of tumor regression characterized by very rapid regression and the involvement of a cytotoxic mechanism.