Oxygenated diterpenes and other constituents from Moroccan Juniperus phoenicea and Juniperus thurifera var. africana
- 作者：Barrero ; Alejandro F. ; Qu脛脛脛脛lez del Moral ; Jos脙脙 F. ; Herrador ; M. Mar ; Akssira ; Mohamed ; et. al.
- 关键词：Juniperus thurifera ; Juniperus phoenicea ; Cupressaceae ; Diterpenoids ; Cytotoxic activity
- 刊名：Phytochemistry
- 出版年：2004
- 期刊代码：85_00319422
- 类别：ch
- 出版时间：September, 2004
- 卷：65
- 期：17
- 页码：2507-2515
- 文件大小：353 K
摘要
Six new diterpenic acids isolated as their methyl ester derivatives, i.e., methyl 12-oxo-8脦脦,15-dihydroxyabiet-13-en-19-oate, methyl 12-oxo-8脦脦-hydroxyabiet-13-en-19-oate, methyl 15-hydroperoxy-8脦脦,12脦脦-epidioxiabiet-13-en-19-oate, methyl 15-hydroxy-8脦脦,12脦脦-epidioxiabiet-13-en-19-oate, methyl 15-hydroperoxy-8脦脦,14脦脦,12脦脦,13脦脦-diepoxiabietan-13-en-19-oate, and methyl 7脦脦,12脦脦-dihydroxysandaracopimarate, together with two new isovalerate derivatives of p-methoxycinnamyl alcohol and linalool, were isolated from the leaves of Juniperus thurifera var. africana and Juniperus phoenicea, grown in Morocco. The structures of these compounds were established by using spectroscopic techniques, including 2D NMR spectra. The cytotoxicity of the abietane diterpenoids was tested against five cell lines.