A new and facile access to the 2-(indol-3-yl)-3-nitriloquinolines based on Friedl盲nder annulations

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• 作者：Morteza Shiri^a ; ^c ; ^{mshiri@alzahra.ac.ir} ; Mohammad Ali Zolfigol^b ; ^{zolfi@basu.ac.ir} ; Mahtab Pirveysian^b ; Roya Ayazi-Nasrabadi^b ; Hendrik G. Kruger^c ; Tricia Naicker^c ; Iraj Mohammadpoor-Baltork^d
• 关键词：Quinolines ; Indoles ; Friedlä ; nder quinoline synthesis ; Ethylene glycol
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：29 July, 2012
• 卷：68
• 期：30
• 页码：6059-6064
• 文件大小：1048 K

摘要

Preparation of 2-(indol-3-yl)-3-nitriloquinolines via Friedl盲nder quinoline synthesis using 3-cyanoacetylindoles possessing an 伪-methylene group and ortho-amino arylketones have been described. This reaction took place in PEG-400 as a green solvent and it is catalyzed with polyphosphoric acid (PPA) to give novel types of quinolines containing both indoles and cyano functions in one step under thermal and microwave conditions.