Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear ß-catenin in inflammatory bowel disease-related oncogenesis
- 作者：Cé ; line Bossard ; Fré ; dé ; rique Souazé ; Anne Jarry ; Sté ; phane Bezieau ; Jean-Franç ; ois Mosnier ; Patricia Forgez ; Christian L. Laboisse
- 关键词：Neurotensin high-affinity receptor 1 (NTS1) ; Neurotensin (NT) ; Inflammatory bowel disease ; Colorectal oncogenesis ; APC/β ; -catenin pathway
- 刊名：Peptides
- 出版年：2007
- 期刊代码：59_01969781
- 类别：neu
- 出版时间：October 2007
- 卷：28
- 期：10
- 页码：2030-2035
- 文件大小：994 K
摘要
We investigated the expression of the neurotensin high-affinity receptor 1 (NTS1) during inflammatory bowel disease (IBD)-related colorectal oncogenesis, in colonic samples from 30 patients with IBD-related adenocarcinomas, dysplasias, and inflammatory mucosa (IM).
The percentage of NTS1-positive epithelial cells progressively increased from the inflammatory condition to adenocarcinoma and was significantly higher in adenocarcinomas than in IM (p = 0.0169). In parallel, the percentage of neurotensin (NT)-positive epithelial cells increased during the IBD-related oncogenesis. Finally, as NTS1 is a ß-catenin inducible gene, we found that a number of preneoplastic lesions and adenocarcinomas co-expressed NTS1 and ß-catenin without NT expression. Therefore, this study suggests two pathways of NTS1 overexpression during IBD-related oncogenesis: one triggered by NT overexpression, and a second associated with an activation of the APC/β-catenin pathway, these two pathways being not mutually exclusive.