Modulation of voltage-gated Na⁺ and K⁺ channels by pumiliotoxin 251D: A “joint venture” alkaloid from arthropods and amphibians

详细信息	查看全文 | 推荐本文 |

• 作者：Thomas V ; endriessche ; Yousra Abdel-Mottaleb ; Chantal Maertens ; Eva Cuypers ; Alex ; er Sudau ; Udo Nubbemeyer ; Dietrich Mebs ; Jan Tytgat
• 关键词：PTX 251D ; PTXs ; VGSC ; VGPC ; Two-electrode voltage clamp technique
• 刊名：Toxicon
• 出版年：2008
• 期刊代码：50_00410101
• 类别：pha
• 出版时间：1 March 2008
• 卷：51
• 期：3
• 页码：334-344
• 文件大小：469 K

摘要

Certain amphibians provide themselves with a chemical defense by accumulating lipophilic alkaloids into skin glands from dietary arthropods. Examples of such alkaloids are pumiliotoxins (PTXs). In general, PTXs are known as positive modulators of voltage-gated sodium channels (VGSCs). Unlike other PTXs, PTX 251D does not share this characteristic. However, mice and insect studies showed that PTX 251D is highly toxic and to date the basis of its toxicity remains unknown.