Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases
- 作者：Suhayl Dhib-Jalbut ; Douglas L. Arnold ; Don W. Cleveland ; Mark Fisher ; Robert M. Friedlander ; M. Maral Mouradian ; Serge Przedborski ; Bruce D. Trapp ; Tony Wyss-Coray and V. Wee Yong
- 关键词：Neurodegeneration ; Neuroprotection ; Multiple sclerosis ; Parkinson's disease ; ALS ; Alzheimer's disease ; Stroke ; Caspase-1 ; Glatiramer acetate
- 刊名：Journal of Neuroimmunology
- 出版年：2006
- 期刊代码：32_01655728
- 类别：neu
- 出版时间：July 2006
- 卷：176
- 期：1-2
- 页码：198-215
- 文件大小：621 K
摘要
Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic neuron depletion; ALS, a disease of motor neuron death; and Alzheimer's, a disease of plaques and tangles. Although these disorders differ in important ways, they also have common pathogenic features, including inflammation, genetic mutations, inappropriate protein aggregates (e.g., Lewy bodies, amyloid plaques), and biochemical defects leading to apoptosis, such as oxidative stress and mitochondrial dysfunction. In most disorders, it remains uncertain whether inflammation and protein aggregation are neurotoxic or neuroprotective. Elucidating the mechanisms that orchestrate neuronal diseases should facilitate development of neuroprotective and neurorestorative strategies.