The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

详细信息	查看全文 | 推荐本文 |

• 作者：Tarek Baati^a ; ^b ; Fanchon Bourasset^c ; Najla Gharbi^d ; Leila Njim^b ; Manef Abderrabba^e ; Abdelhamid Kerkeni^b ; Henri Szwarc^d ; Fathi Moussa^d ; ^{fathi.moussa@u-psud.fr}
• 关键词：Fullerenes ; Toxicity ; Pharmacokinetics ; Ageing ; Oxidative stress
• 刊名：Biomaterials
• 出版年：2012
• 期刊代码：7_01429612
• 类别：ms
• 出版时间：June, 2012
• 卷：33
• 期：19
• 页码：4936-4946
• 文件大小：1647 K

摘要

Countless studies showed that [60]fullerene (C₆₀) and derivatives could have many potential biomedical applications. However, while several independent research groups showed that C₆₀ has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the in聽vivo fate and the chronic effects of this fullerene remain unknown. If the potential of C₆₀ and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of C₆₀ dissolved in olive oil (0.8聽mg/ml) at reiterated doses (1.7聽mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan. The effects of C₆₀-olive oil solutions in an experimental model of CCl₄ intoxication in rat strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Pharmacokinetic studies show that dissolved C₆₀ is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C₆₀ including cancer therapy, neurodegenerative disorders, and ageing.