Dose-response in stereotactic irradiation of lung tumors

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• 作者：Joern Wulf ; Kurt Baier ; Gerd Mueller and Michael P. Flentje
• 关键词：Stereotactic radiotherapy ; Dose escalation ; Non-small cell lung cancer ; Lung metastases
• 刊名：Radiotherapy and Oncology
• 出版年：2005
• 期刊代码：231_01678140
• 类别：med
• 出版时间：2005
• 卷：77
• 期：1
• 页码：83-87
• 文件大小：86 K

摘要

The dose-response for local tumor control after stereotactic radiotherapy of 92 pulmonary tumors (36 NSCLC and 56 metastases) was evaluated. Short course irradiation of 1–8 fractions with different fraction doses was used. After a median follow-up of 14 months (2–85 months) 11 local recurrences were observed with significant advantage for higher doses. When normalization to a biologically effective dose (BED) is used a dose of 94 Gy at the isocenter and 50 Gy at the PTV-margin are demonstrated to give 50%probability of tumor control (TCD50). Multivariate analysis revealed the dose at the PTV-margin as the only significant factor for local control.