A multidisciplinary approach for the analysis of an adulterated dietary supplement where the active pharmaceutical ingredient was embedded in the capsule shell

详细信息	查看全文 | 推荐本文 |

• 作者：Adam Lanzarotta ; ^{adam.lanzarotta@fda.hhs.gov} ; John B. Crowe ; Mark Witkowski ; Bryan M. Gamble
• 关键词：Infrared imaging ; Raman spectroscopy ; Optical microscopy ; LC/MS ; Dietary supplement ; Adulteration
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2012
• 期刊代码：65_07317085
• 类别：ch
• 出版时间：August-September, 2012
• 卷：67-68
• 期：Complete
• 页码：22-27
• 文件大小：623 K

摘要

Fourier transform infrared (FT-IR) microspectroscopic imaging, Raman microspectroscopy, optical microscopy and high performance liquid chromatography with mass spectrometric (LC/MS) detection were employed to examine a dietary supplement adulterated with an undeclared active pharmaceutical ingredient (API). While a trace level of the API was detected in the capsule contents, a higher concentration of API was found in the capsule shell, which indicated the use of an unconventional manufacturing process to hide the API and thus avoid detection. This study demonstrates the need for a multidisciplinary approach to provide a complete assessment of a suspect adulterated dietary supplement.