• 作者：A. Dí ; az Negrillo^a ; ^{antoniodnegrillo@yahoo.es} ; F. Martí ; n del Valle^b ; M. Gonzá ; lez Salaices^a ; C. Prieto Jurczynska^a ; J. Carneado Ruiz^a
• 关键词：Infancia ; Epilepsia ; Electroencefalograma ; Sí ; ndrome de Lennox-Gastaut ; Levetiracetam
• 刊名：Neurolog铆a
• 出版年：2011
• 期刊代码：pca262_02134853
• 类别：med
• 出版时间：June 2011
• 卷：26
• 期：5
• 页码：285-290
• 文件大小：1056 K

Introduction

The Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies of childhood, characterized by electro-clinical triad of generalized spike-wave activity, slow (POL) in the electroencephalogram (EEG), multiple types of seizures and development delay. This paper intends to describe the syndrome in a patient with a history of hypoxic-ischaemic encephalopathy and Lennox-Gastaut syndrome, and a good response to treatment with levetiracetam (LEV).

Method

Descriptive study on the development of a 3 year old child with intrauterine asphyxia, multiorgan failure, metabolic acidosis, hypovolemic shock, and seizures with cerebral oedema, who developed a West syndrome, resistant to drug treatment. The semiology of seizures progressively changed to generalized episodes of hypertonia and myoclonus, with slow spike-wave electroencephalographic activity.

Results

With the diagnosis of Lennox-Gastaut syndrome the patient was treated with levetiracetam, showing a substantial improvement in the cognitive sphere, in the control of seizures, and electroencephalographic findings.

Conclusions

Lennox-Gastaut syndrome is one of the most severe epileptic syndromes in paediatric patients. Levetiracetam can help cognitive improvement, and contribute to seizure control in these patients.