Association of pre-operative interleukin-6 levels with Interagency Registry for Mechanically Assisted Circulatory Support profiles and intensive care unit stay in left ventricular assist device patients

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• 作者：Raffaele Caruso ; MSc^a ; Alessandro Verde ; MD^b ; Manuela Cabiati ; MSc^c ; Filippo Milazzo ; MD^b ; Chiara Boroni ; BTSc^a ; Silvia Del Ry ; ScD^c ; Marina Parolini ; BStat^a ; Claudia Vittori ; MD^b ; Roberto Paino ; MD^b ; Luigi Martinelli ; MD^b ; Daniela Giannessi ; CHs^c ; Maria Frigerio ; MD^b ; Oberdan Parodi ; MD^a ; ^{ifcnig@tin.it}
• 关键词：End-stage heart failure ; cytokines ; LVAD ; osteopontin ; INTERMACS
• 刊名：The Journal of Heart and Lung Transplantation
• 出版年：2012
• 期刊代码：161_10532498
• 类别：med
• 出版时间：June, 2012
• 卷：31
• 期：6
• 页码：625-633
• 文件大小：464 K

摘要

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Background

Inflammatory mechanisms are associated with worse prognosis in end-stage heart failure (ESHF) patients who require left ventricular assist device (LVAD) support. Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profiles describe patient condition at pre-implant and outcome. This study assessed the relationship among inflammation patterns and INTERMACS profiles in LVAD recipients.

Method

Thirty ESHF patients undergoing LVAD implantation as bridge to transplant were enrolled. Blood and urine samples were collected pre-operatively and serially up to 2 weeks post-operatively for assessment of inflammatory markers (plasma levels of interleukin [IL]-6, IL-8, IL-10, and osteopontin, a cardiac inflammatory-remodeling marker; and the urine neopterin/creatinine ratio, a monocyte activation marker). Multiorgan function was evaluated by the total sequential organ failure assessment (tSOFA) score. Outcomes of interest were early survival, post-LVAD tSOFA score, and intensive care unit (ICU) length of stay.

Results

Fifteen patients had INTERMACS profiles 1 or 2 (Group A), and 15 had profiles 3 or 4 (Group B). At pre-implant, only IL-6 levels and the IL-6/IL-10 ratio were higher in Group A vs B. After LVAD implantation, neopterin/creatinine ratio and IL-8 levels increased more in Group A vs B. Osteopontin levels increased significantly only in Group B. The tSOFA score at 2 weeks post-LVAD and ICU duration were related with pre-implant IL-6 levels.

Conclusions

The INTERMACS profiles reflect the severity of the pre-operative inflammatory activation and the post-implant inflammatory response, affecting post-operative tSOFA score and ICU stay. Therefore, inflammation may contribute to poor outcome in patients with severe INTERMACS profile.