Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase

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• 作者：Ting Wang ; Hyun Joo Lee ; Dilip K. Tosh ; Hea Ok Kim ; Shantanu Pal ; Sun Choi ; Yoonji Lee ; Hyung Ryong Moon ; Long Xuan Zhao ; Kang Man Lee ; Lak Shin Jeong
• 关键词：S-Adenosylhomocysteine hydrolase ; 5′ ; -Ureidoadenosine ; Multiple hydrogen bonding donor
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 August 2007
• 卷：17
• 期：16
• 页码：4456-4459
• 文件大小：253 K

摘要

5′-Deoxy-5′-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5′-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.