Pulmon
ary drug delivery of
controlled rele
ase formul
ations m
ay provide
an effe
ctive
adjun
ct
appro
ach to or
ally delivered
antibioti
cs for
cle
aring persistent lung infe
ctions. Dry powder formul
ations for this indi
cation should possess
ch
ar
acteristi
cs in
cluding; effe
ctive deposition to infe
cted lung
comp
artments, persisten
ce
at the infe
ction site,
and ste
ady rele
ase of
antibioti
c. L
arge porous p
arti
cles (
![]()
c="http://www.s
cien
cedire
ct.
com/s
cidirimg/entities/223
c.gif"
alt="not, vert, simil
ar" border=0> 10–15;
c;m) h
ave demonstr
ated effe
ctive lung deposition
and enh
an
ced lung residen
ce
as
a result of their l
arge di
ameter
and redu
ced
cle
ar
an
ce by m
acroph
ages in
comp
arison to sm
all mi
crop
arti
cles (
![]()
c="http://www.s
cien
cedire
ct.
com/s
cidirimg/entities/223
c.gif"
alt="not, vert, simil
ar" border=0> 1–5;
c;m). In this report, Pre
cision P
arti
cle F
abri
cation te
chnology w
as used to
cre
ate monodisperse l
arge porous p
arti
cles of poly(
an class="smCaps">dan>,
an class="smCaps">lan>-l
acti
c-
co-gly
coli
c acid) (PLGA) utilizing oils
as extr
act
able porogens. After extr
action, the resulting l
arge porous PLGA p
arti
cles exhibited
a low density
and
a web-like or hollow interior depending on porogen
con
centr
ation
and type, respe
ctively. Ciproflox
acin n
anop
arti
cles (n
anoCipro)
cre
ated by homogeniz
ation in di
chlorometh
ane, possessed
a polymorph with
a de
cre
ased melting temper
ature. En
capsul
ating n
anoCipro in l
arge porous PLGA p
arti
cles resulted in
a ste
ady rele
ase of
ciproflox
acin th
at w
as extended for l
arger p
arti
cle di
ameters
and for the solid p
arti
cle morphology in
comp
arison to l
arge porous p
arti
cles. The en
capsul
ation effi
cien
cy of n
anoCipro w
as quite low
and f
actors imp
acting the entr
apment of n
anop
arti
cles during p
arti
cle form
ation were elu
cid
ated. A dry powder formul
ation with the potenti
al to
control p
arti
cle deposition
and sust
ain rele
ase to the lung w
as developed
and insight to improve n
anop
arti
cle en
capsul
ation is dis
cussed.